Publications

• Kokan N., Lin C., Luna A., Viliunas J., Rankin C.H. (2025). Ethanol alters mechanosensory habituation in C. elegans by way of the BK potassium channel through a novel mechanism. PLoS One. 20(6):e0315069.
• Parvand M., Liang J.J.H., Bozorgmehr T., Born D., Luna Cortes A., Rankin C.H. (2024). A familial Alzheimer’s disease associated mutation in presenilin-1 mediates amyloid-beta independent cell specific neurodegeneration. PLoS One. 19(9):e0289435
• Chalissery J., Wilson I., Rankin C.H., Liang J. (2023). Rearing C. elegans on Parafilm-wrapped NGM Plates Impacts Habituation Behavior. MicroPubl Biol. 10.17912.
• Feresten A.H., Bhat J.M., Yu A.J., Zapf R., Rankin C.H., Hutter H. (2023). wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background. Genetics. 223(3):iyac187.
• Rose J.K., Butterfield M., Liang J., Parvand M., Lin C.H.S., Rankin C.H. (2022). Neuroligin Plays a Role in Ethanol-Induced Disruption of Memory and Corresponding Modulation of Glutamate Receptor Expression. Front Behav Neurosci. 16:908630.
• Kepler L.D., McDiarmid T.A., Rankin C.H. (2022). Rapid assessment of the temporal function and phenotypic reversibility of neurodevelopmental disorder risk genes in Caenorhabditis elegans. Dis Model Mech. 15(5):dmm049359
• Feresten A.H., Bhat J.M., Yu A.J., Zapf R., Safi H., Au V., Flibotte S., Doell C., Moerman D.G., Hawkins N., Rankin C.H., Hutter H. (2022). ccd-5, a novel cdk-5 binding partner, regulates pioneer axon guidance in the ventral nerve cord of Caenorhabditis elegans. Genetics, 220(4), iyac024.
• Yu A.J., Rankin C.H. (2021). Neurobiology: From genome and connectome to understanding behavior. Current Biology 31 (19), R1135-R1138.
• Reiss A.P. , Rankin C.H. (2021). Gaining an understanding of behavioral genetics through studies of foraging in Drosophila and learning in C. elegans. Journal of Neurogenetics, 35 (3), 119-131.
• Rankin, C. H. (2020). But can they learn? my accidental discovery of learning and memory in C. elegans. Journal of Neurogenetics, 34(3-4), 251-254.
• McDiarmid, T. A., Au, V., Moerman, D. G., & Rankin, C. H. (2020). Peel-1 negative selection promotes screening-free CRISPR-Cas9 genome editing in caenorhabditis elegans. PloS One, 15(9), e0238950-e0238950
• Liang, J. J. H., McKinnon, I. A., & Rankin, C. H. (2020). The contribution of C. elegans neurogenetics to understanding neurodegenerative diseases. Journal of Neurogenetics, 34(3-4), 527-548
• De Fruyt, N., Yu, A. J., Rankin, C. H., Beets, I., & Chew, Y. L. (2020). The role of neuropeptides in learning: Insights from C. elegans. The International Journal of Biochemistry & Cell Biology, 125, 105801-105801
• McDiarmid, T. A., Kepler, L. D., & Rankin, C. H. (2020). Auxin does not affect a suite of morphological or behavioral phenotypes in two wild-type C. elegans strains. MicroPublication Biology, 2020
• Kepler, L. D., McDiarmid, T. A., & Rankin, C. H. (2020). Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. Neurobiology of Learning and Memory, 171, 107208-107208. 
• Post, K. L., Belmadani, M., Ganguly, P., Meili, F., Dingwall, R., McDiarmid, T. A., Meyers, W. M., Herrington, C., Young, B. P., Callaghan, D. B., Rogic, S., Edwards, M., Niciforovic, A., Cau, A., Rankin, C. H., O’Connor, T. P., Bamji, S. X., Loewen, C. J. R., Allan, D. W., . . . Haas, K. (2020). Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction. Nature Communications, 11(1), 2073-2073. 
• McDiarmid, T. A., Belmadani, M., Liang, J., Meili, F., Mathews, E. A., Mullen, G. P., Hendi, A., Wong, W., Rand, J. B., Mizumoto, K., Haas, K., Pavlidis, P., & Rankin, C. H. (2020). Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation. Proceedings of the National Academy of Sciences – PNAS, 117(1), 656-667. 
• Boycott, K. M., Campeau, P. M., Howley, H. E., Pavlidis, P., Rogic, S., Oriel, C., Berman, J. N., Hamilton, R. M., Hicks, G. G., Lipshitz, H. D., Masson, J., Shoubridge, E. A., Junker, A., Leroux, M. R., McMaster, C. R., Michaud, J. L., Turvey, S. E., Dyment, D., Innes, A. M., . . . Hieter, P. (2020). The canadian rare diseases models and mechanisms (RDMM) network: Connecting understudied genes to model organisms. American Journal of Human Genetics, 106(2), 143-152. 
• Parvand, M., & Rankin, C. H. (2020). Is there a shared etiology of olfactory impairments in normal aging and neurodegenerative disease? Journal of Alzheimer’s Disease, 73(1), 1-21. 
• Formisano, R., Mersha, M. D., Caplan, J., Singh, A., Rankin, C. H., Tavernarakis, N., & Dhillon, H. S. (2020). Synaptic vesicle fusion is modulated through feedback inhibition by dopamine auto‐receptors. Synapse (New York, N.Y.), 74(1), e22131-n/a
• McDiarmid, T. A., Yu, A. J., & Rankin, C. H. (2019). Habituation is more than learning to ignore: Multiple mechanisms serve to facilitate shifts in behavioral strategy. Bioessays, 41(9), e1900077-n/a
• Loucks, C. M., Park, K., Walker, D. S., McEwan, A. H., Timbers, T. A., Ardiel, E. L., Grundy, L. J., Li, C., Johnson, J., Kennedy, J., Blacque, O. E., Schafer, W., Rankin, C. H., & Leroux, M. R. (2019). EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling. Elife, 8
• Yu, A. J., McDiarmid, T. A., Ardiel, E. L., & Rankin, C. H. (2019). High‐Throughput Analysis of Behavior Under the Control of Optogenetics in Caenorhabditis elegans. Current protocols in neuroscience, 86(1), e57.
• Chew, Y. L., Tanizawa, Y., Cho, Y., Zhao, B., Alex, J. Y., Ardiel, E. L., … & Beets, I. (2018). An afferent neuropeptide system transmits mechanosensory signals triggering sensitization and arousal in C. elegans. Neuron, 99(6), 1233-1246.
• Zhang, S., Cai, F., Wu, Y., Bozorgmehr, T., Wang, Z., Zhang, S., … & Tang, B. (2018). A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling. Molecular psychiatry, 1.
• McDiarmid, T. A., Au, V., Loewen, A. D., Liang, J., Mizumoto, K., Moerman, D. G., & Rankin, C. H. (2018). CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance. Disease models & mechanisms, dmm-036517.
• McDiarmid, T. A., Yu, A. J., & Rankin, C. H. (2018). Beyond the response–high throughput behavioral analyses to link genome to phenome in Caenorhabditis elegans. Genes, Brain and Behavior.
• Ardiel, E. L., Alex, J. Y., Giles, A. C., & Rankin, C. H. (2017). Habituation as an adaptive shift in response strategy mediated by neuropeptides. npj Science of Learning, 2(1), 9.
• McDiarmid, T. A., Bernardos, A. C., & Rankin, C. H. (2017). Habituation is altered in neuropsychiatric disorders—a comprehensive review with recommendations for experimental design and analysis. Neuroscience & Biobehavioral Reviews.
• Ardiel, E. L., Giles, A. C., Alex, J. Y., Lindsay, T. H., Lockery, S. R., & Rankin, C. H. (2016). Dopamine receptor DOP-4 modulates habituation to repetitive photoactivation of a C. elegans polymodal nociceptor. Learning & Memory, 23(10), 495-503.
• Petley-Ragan, LM.,, Ardiel, EL,, Rankin, CH and Auld, VJ (2016) Accumulation of laminin monomers in Drosophila glia leads to glial ER stress and disrupted larval locomotion, Journal of Neuroscience 
• Giles, AC., Opperman, KJ., Rankin, CH and Grill, B (2015) Developmental Function of the PHR Protein RPM-1 Is Required for Learning in Caenorhabditis elegans. G3 Published on 13 Oct 2015,   doi: 10.1534/g3.115.021410
• Ardiel EL, Rankin CH (2015) Cross-referencing online activity with the connectome to identify a neglected, but well-connected neuron. Current Biology
• Ardiel EL, Rankin CH (2015) Casting a genome-wide net for learning mutants. Neuron, 85:1147-8.
• McDiarmid, TA, Ardiel, EL, Rankin, CH (2015) The role of neuropeptides in learning and memory in C. elegans, Current Opinion in Behavioural Sciences 2: 15-20 
• Rankin, C. H. (2015). A review of transgenerational epigenetics for RNAi, longevity, germline maintenance and olfactory imprinting in Caenorhabditis elegans. Journal of Experimental Biology, 218(1), 41-49.
• Timbers, TA, Giles, AC, Ardiel, EA, Kerr, (2013) Intensity discrimination deficits cause habituation changes in middle-aged C. elegans, Neurobiology of Aging Neurobiology of Aging 34(2):621-31
• Lau, HL, Timbers, TA, McEwan,AH, and Bozorgmehr, T. and Rankin CH (2013) Genetic Dissection of Memory for Associative and Non-Associative Learning in C. elegans. Genes, Brain and Behavior. doi: 10.1111/j.1601-183X.2012.00863.
• Li, C. , Rose, J., Timbers, T.A., McEwan, A, Bozorgmehr, T. & Rankin, C. H. (2013) The FMRFamide-related neuropeptide FLP-20 is required in the mechanosensory neurons during memory for massed training in C. elegans. Learning and Memory Jan 16;20(2):103-8. doi: 10.1101/lm.028993.112.
• Lin, HSC, Sa, S., Chand, J. and Rankin, CH (2012) Dynamic and persistent effects of ethanol exposure on development: an in vivo analysis during and after embryonic ethanol exposure in C. elegans Alcoholism: Clinical and Experimental Research. doi: 10.1111/j.1530-0277.2012.01856.x.
• Swierczek, N*.,  Giles, A*, Rankin CH and Kerr R, (2011) High-throughput behavioral analysis in C. elegans, Nature MethodsJun 5;8(7):592-8 (*both authors contributed equally).
• Timbers, T.A. and Rankin, C.H. (2011). Tap withdrawal interneurons require CREB for Long-Term Memory for Habituation Training in Caenorhabditis elegans. Behavioral Neuroscience. Epub 2011 June 11
• Ardiel, E.L. and Rankin, C.H.  (2011) Some like it hot: decoding neurotransmission in the worm’s thermotaxis circuit. The EMBO Journal 30, 1192 – 1194
• Shikano, I., .Aktar, Y. Isman, M.B. and Rankin, C. H. (2010) Dishabituation of long-term memory for gustatory habituation in the cabbage looper, Trichoplusia Behavioral Neuroscience , Vol 124(5),  701-705
• Ardiel EL, Rankin CH. (2009) C. elegans: social interactions in a “nonsocial” animal. Adv Genet; 68:1-22.
• Ardiel, E.L. & Rankin, C.H. (2010) An Elegant Mind: Leaning and Memory in C. elegans. Learning and Memory 17: 191-201
• Ardiel, E.L. & Rankin, C.H. (2010) The importance of touch in development. Paediatrics & Child Health, 15: 153-156
• Taghibiglou C., Martin, H. S., Rose, J. K., Ivanova, N., Lin, C., Lau, H. L., Rai, S., Wang, Y. T., & Rankin, C. H. (2009) Essential role of SBP-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans. FEBS Letters, 583; 831-834
• Giles, A.C. and Rankin, C.H. (2008) Behavioral and Genetic Characterization of Habituation using Caenorhabditis elegans Neurobiology of Learning and Memory 92, 139-146.
• Rankin, CH, Abrams,T., Barry, RJ., Bhatnagar,S. Clayton, D., Colombo,J., Coppola,G., Geyer,MA., Glanzman, DL. Marsland, S., McSweeney,F., Wilson,DA., Wu, CF., and Thompson, RF (2008) Habituation Revisited: An Updated and Revised Description of the Behavioral Characteristics of Habituation. Neurobiology of Learning and Memory 92, 135-138
• Ardiel, E.A. and Rankin, C.H. (2008) Behavioral Plasticity in the C. elegans Mechanosensory Circuit, J Neurogenet. 15:1-18
• Davis, J. R. Li, Y. and Rankin, C. H. (2008) Effects of developmental exposure to ethanol on Caenorhabditis elegans. Clinical and Experimental Research 32(5), 1-15.
• Kindt, K.S., Quast, K.B., Giles, A.C., Hendrey, D., Nicastro, I,. Rankin, C. H. and Schafer, W.R (2007) Dopamine mediates food dependent modulation of sensory plasticity in C. elegans.  Neuron 55 (4), 662-676.
• Rai, S. and Rankin, C.H. (2007) Critical and sensitive periods for reversing the effects of mechanosensory deprivation on behavior, nervous system, and development in caenorhabditis elegans. Developmental Neurobiology, 67(11), 1443-1456. doi:10.1002/dneu.20522
• Ebrahimi, C.M., and Rankin, C.H. (2006) Early patterned stimulation leads to changes in adult behavior and gene expresion in C. elegans. Genes, Brain and Behaviour, 6(6), 517-528. doi:10.1111/j.1601-183X.2006.00278.x
• Rankin, C. H. (2006). Nematode behavior: The taste of success, the smell of danger. Current Biology, 16(3), E89-E91. doi:10.1016/j.cub.2006.01.025
• Rose,J.K., and Rankin, C.H. (2006) Blocking memory reconsolidation reverses memory-associated changes in glutamate receptor expression. Journal of Neuroscience 26 (45), 11582-11587.
• Rose, J.K., Sangha, S., Rai, S., Norman, K.R. and Rankin, C.H. (2005) Decreased sensory stimulation reduces behavioral responding, retards development, and alters neuronal connectivity in Caenorhabditis elegans. Journal of Neuroscience 25 (31), 7159-7168.
• Rankin, C.H. (2004) Invertebrate learning: what can’t a worm learn? Current Biology  14, R617-R618, August 10, 2004.
• Rose, JK, Kaun, KR, Chen, SH and Rankin, CH (2003) GLR-1, a non-NMDA glutamate receptor homolog, is critical for long-term memory in Caenorhabditis elegans.  Journal of Neuroscience 23 (29), 9595-9600.
• Akhbar, Y., Rankin, C.H. and Isman, M.B. (2003) Decreased response to feeding deterrents following prolonged exposure in the larvae of a generalist herbivore, Trichoplusia ni (Lepidoptera: Noctuidae). Journal of Insect Behavior 16 (6), 833-831.
• Rankin, C. H. (2002) From gene to identified neuron to behaviour in Caenorhabditis elegans, Nature Reviews Genetics, 3, 622-630.
• Rose, J.K., Kaun, K.R. and Rankin, C.H. (2002) A New Group Training Procedure for Habituation Demonstrates That Presynaptic Glutamate Release Contributes to Long-Term Memory in C. elegans.  Learning and Memory, 9,130-137.
• Rankin, C. H. (2002) Neuroscience. A bite to remember, Science 296, 1624-1625.
• Rose, J. K. &Rankin, C.H. (2001) Analyses of Habituation in C. elegans, Learning and Memory, 8, 63-69.
• Siklos, S. Jasper, J. A., Wicks, S. R., & Rankin, C. H.  (2000).  Interactions Between an Endogenous Oscillator and an Evoked Response in C. elegans.  Psychobiology.  [not available online]
• Rankin, C. H. (2000) Context conditioning in habituation in the nematode Caenorhabditis elegans. Behavioral Neuroscience 114, 496-505.
• Rankin, C.H. and Wicks, S.R. (2000) Mutations of the Caenorhabditis elegans brain specfic inorganic phosphate transporter, eat-4, affecting habituation of the tap-withdrawal response without affecting the response itself.  J. Neuroscience.20, 4337-4344.
• Rankin, C. H.,  Wicks, S.R. & Gannon, T. N. (2000) Developmental analysis of habituation in the nematode C. elegans. Developmental Psychobiology.36, 261-270.
• Roehrig, C.J. and Rankin, C.H. (1999) Dymods: A framework for modularizing dynamical neuronal structures. Neurocomputing 26-27,  831-836.
• Beck, C.D. O and Rankin, C.H. (1997) Long-term habituation is produced by distributed training at long ISIs and not by massed training at short ISIs in Caenorhabditis elegans. Animal Learning and Behavior.25, 446-457.
• Wicks, S. R., & Rankin, C. H. (1997). Effects of tap withdrawal response habituation on other withdrawal behaviors: the localization of habituation in the nematode Caenorhabditis elegans. Behavioral Neuroscience, 111, 342-353.
• Wicks, S. R., & Rankin, C. H. (1996). The integration of antagonistic reflexes revealed by laser ablation of identified neurons determines habituation kinetics of the Caenorhabditis elegans tap withdrawal response. Journal of Comparative Physiology A, 179, 675-685.
• Wicks, S. R., Roehrig, C. J., and Rankin, C. H. (1996). A dynamic network simulation of the nematode tap withdrawal circuit: Predictions concerning synaptic function using behavioral criteria. Journal of Neuroscience, 16, 4017-4031. 
• Wicks, S. R., & Rankin, C. H. (1996). Recovery from habituation in Caenorhabditis elegans is dependent on interstimulus interval and not habituation kinetics. Behavioral Neuroscience, 110, 840-844.
• Beck, C. D. O., & Rankin, C. H. (1995). Heat shock disrupts long term memory in Caenorhabditis elegans. Learning and Memory, 2, 161-177.
• Wicks, S. R., & Rankin, C. H. (1995). Integration of mechanosensory stimuli in Caenorhabditis elegans. Journal of Neuroscience, 15, 2434-2444.
• Broster, B. S., & Rankin, C. H. (1994). Effects of changing interstimulus interval during habituation in Caenorhabditis elegans. Behavioral Neuroscience, 108, 1019-1029. 
• Beck, C. D. O., & Rankin, C. H. (1993). Effects of aging on habituation in the nematode Caenorhabditis elegans. Behavioral Processes, 28, 145-164.
• Mah, K. B., & Rankin, C. H. (1992). An analysis of behavioral plasticity in male Caenorhabditis elegans. Behavioral and Neural Biology, 58, 211-221.
• Rankin, C. H., & Broster, B. (1992). Factors affecting habituation and rate of recovery from habituation in C. elegans. Behavioral Neuroscience 106, 239-249.
• Rankin, C. H. (1991). Interactions between two antagonistic reflexes in the nematode Caenorhabditis elegans. Journal of Comparative Physiology A, 59-67.
• Chiba, C. M., & Rankin, C.H. (1990). A developmental analysis of spontaneous and reflexive reversals in the nematode Caenorhabditis elegans. Journal of Neurobiology, 21(4), 543-554.
• Rankin, C. H., Chiba, C., & Beck, C. (1990). Caenorhabditis elegans: A new model system for the study of learning and memory. Behavioral Brain Research, 37, 89-92.

Book Chapters and Reviews

• Giles, A.C., Rose, J.K., and Rankin, C.H. (2006). Investigations of learning and memory in Caenorhabditis elegans. Neurobiology of C. elegans International Review of Neurobiology 69, 37-71.
• Holmes, C. , Tanchuk, T. L., Galloway, J. A., & Peters, K. R.  (2004).  Memory in fruit flies and nematodes.  In Encyclopedia of Life Sciences.  London, MacMillan Reference Limited Stockton Press.  (on line)
• Steidl,S., Rose, J. K. and Rankin. C. H. (2003) Stages of Memory in the nematode Caenorhabditis elegans. Behavioral and Cognitive Neuroscience Reviews 2 (1), 3-14.
• Steidl, S. and Rankin, C. H. (2003) C. elegans as a model system for learning and memory.  In Byrne, J.H., ed., Learning and Memory, Second edition, New York, J.H. Macmillan Publishing Company, 2003.
• Eng, K., Rose, J. K., & Rankin, C. H.  (2002).  Learning in simple organisms.  In Encyclopedia of Cognitive Science.  London, MacMillan Reference Limited, Stockton Press.
• Tanchuk, T. L., Galloway, J. A., & Peters, K. R.  (2000).  Memory in fruit flies and nematodes.  In Encyclopedia of Life Sciences.  London, MacMillan Reference Limited Stockton Press.  (on line)
• Peters, K. R., Galloway, J. A., & Rankin, C. H.  (1999).  Caenorhabditis elegans and the genetics of learning.  In W. E. Crusio & R. Gerlai (Eds.), Molelcular genetic techniques for behavioral neuroscience (pp. 551-568).  Amsterdam, Elsevier.
• Jorgenson, E., & Rankin, C. H. (1997). Plasticity in the nervous system of C. elegans. In D. L. Riddle, T. Blumenthal, B. J. Meyer, & J. R. Priess (Eds.), C. elegans II.  New York: Cold Spring Harbor Press.
• Gannon, T. N., & Rankin, C. H. (1995). Methods of studying behavioral plasticity in Caenorhabditis elegans .In H. F. Epstein & D. C. Shakes (Eds.), Caenorhabditis elegans: Modern biological analysis of an organism. Methods in Cell Biology Series Vol.48. San Diego: Academic Press.
• Rankin, C. H. (1994). Mechanistic questions raised by a behavioral analysis of habituation in Caenorhabditis elegans. Seminars in Neuroscience, 6, 3-10.
• Rankin, C. H., & Beck, C. D. O. (1992). Caenorhabditis elegans: a simple systems approach to the genetics of behavior. In Goldowitz, D., Wahlsten, D., & Wimer, R. (Eds.), Techniques for the genetic analysis of brain and behavior: Focus on the mouse. Amsterdam: Elsevier.